The economic lobbyist community known as The Big Club is represented most visibly by the U.S. Chamber of Commerce and Tom Donohue.
Via the Wall Street community, CoC President Donohue pours tens of millions of multinational corporate contributions into DC lobbying efforts to retain control over politicians and legislation that relates to U.S. trade and economic matters. [FYI Donohue’s Chamber of Commerce lobbying group were the primary architects of the now dispatched TPP trade deal; they actually wrote the U.S. part of the construct.]
Tom Donohue funds a large number of politicians in DC in an effort to control the outcomes of legislation and policies that could become adverse to his multinational interests. Two of those primary beneficiaries are John McCain and Ben Sasse.
As a consequence it doesn’t come as a surprise to see McCain and Sasse announce their intention to block the confirmation of U.S. Trade Representative Robert Lighthizer:

REUTERS – Republican U.S. Senators John McCain and Ben Sasse said on Wednesday they would vote against President Donald Trump’s nominee for U.S. trade representative, Robert Lighthizer, because of his opposition to the North American Free Trade Agreement.
“Unfortunately, your confirmation process has failed to reassure us that you understand the North American Free Trade Agreement’s (NAFTA) positive economic benefits to our respective States and the nation as a whole,” McCain and Sasse said in a letter to Lighthizer. (read more)
Commerce Secretary Wilbur Ross, Treasury Secretary Steven Mnuchin and President Trump strongly support Lighthizer for U.S. Trade Rep. The institutional control agents within K-Street, aka the economic lobbying group, do not.
(more…)
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